Melatonin vape pen

Melatonin vape pen (a device that vaporizes and delivers components such as melatonin to users for inhalation) claims to help with sleep or relaxation. However, there is no scientific evidence to support its safety or effectiveness.

 Product Positioning and Ingredients
These products are typically positioned as "healthy e-cigarettes" or "aromatherapy diffusers" that do not contain nicotine.

Main ingredients: Besides melatonin, they usually contain herbal extracts such as lavender and chamomile.

Base solvents: To produce vapor, solvents such as propylene glycol (PG) and vegetable glycerin (VG) are added.

Other additives: Some products may also contain L-theanine, vitamin B12, and even caffeine.

⚠️ Key Risks: Why not to use
Although the merchants promote it as "natural" and "risk-free", medical experts and multiple studies have pointed out that it has serious health risks.

Lack of safety and effectiveness data: Currently, there are no clinical data to support the safety of inhaling melatonin. Doctors clearly state that from a medical perspective, this practice is not recommended.

Direct harm to the lungs:

Cell and gene effects: A 2024 study found that melatonin e-cigarettes have a negative impact on human bronchial epithelial cells and lead to the expression of immunosuppressive genes.

Physical damage: The vapor inhaled can stimulate and cause inflammation, resulting in symptoms such as coughing, asthma, and shortness of breath. For patients with asthma or chronic lung diseases, the risk is higher.

Oil-based substance risks: Some products contain essential oils or carrier oils, which can cause lipoid pneumonia when inhaled into the lungs.

Harmful and unknown chemical substances:

Pollutants: Tests have found that commercially available products contain potential pollutants such as drugs and industrial chemicals.

Pyrolysis products: Melatonin decomposes rapidly at temperatures above 60°C. The temperature generated by the e-cigarette heating may cause it to decompose into unknown and potentially harmful chemicals.

Volatile organic compounds (VOCs): The heating process generates VOCs, which can irritate the respiratory tract and stimulate it over time.

Uncontrolled dosage: Unlike traditional pills or gummies, the dosage of melatonin inhaled through an e-cigarette is difficult to precisely control, increasing the risk of overconsumption.

A frequently overlooked paradox: Electronic cigarettes disrupt sleep themselves
What is more notable is that a 2026 study found that the use of electronic cigarettes significantly reduces the body's endogenous melatonin levels. This means that using electronic cigarettes to help sleep may actually have the opposite effect, by disrupting the circadian protein and increasing the risk of cardiovascular diseases.