Has anyone gotten lung cancer from vaping?

Yes, at present, there are an increasing number of case reports and scientific studies linking e-cigarettes to lung cancer.
Although the long-term effects of e-cigarettes on health are still under investigation, the available evidence indicates that they are not a safe alternative to traditional cigarettes and increase the risk of lung cancer.
Alerting Case Reports
Multiple cases related to lung cancer caused by e-cigarettes have been reported in medical journals. The common feature of these cases is that the patients are usually young and have no history of long-term smoking, which is different from the characteristics of the high-risk groups for traditional lung cancer.
A 22-year-old woman with advanced lung cancer: A 22-year-old British woman who started using e-cigarettes at the age of 15 has been diagnosed with advanced lung cancer and has only about 18 months left to live. There is no history of lung cancer in her family. The symptoms appeared after she switched to using disposable e-cigarettes. This case has been reported by multiple media outlets.
A 24-year-old female, with multifocal non-small cell lung cancer: A 24-year-old female with a long history of using CBD (cannabidiol) e-cigarettes has been diagnosed with multifocal non-small cell lung cancer (NSCLC).
51-year-old male, invasive squamous cell carcinoma: A 51-year-old male with a 11-year history of e-cigarette use and a 10-year history of smoking was diagnosed with invasive advanced lung squamous cell carcinoma and passed away 3 months after the diagnosis.
A 61-year-old male, the first case related in Malaysia: A 61-year-old male who had a 29-year history of smoking and then switched to e-cigarettes. His case is considered the first reported case of lung cancer related to e-cigarettes in Malaysia.
Epidemiological research data
Large-scale case-control studies have provided more comprehensive risk data:
Risk has multiplied: A study published in the Journal of Cancer Research and Treatment in 2024 analyzed nearly 5,000 lung cancer patients and over 27,000 control subjects. The results showed:
E-cigarettes + Smoking: People who use both e-cigarettes and traditional cigarettes have a lung cancer risk that is four times higher than that of smokers alone.
Increased risk: After adjusting for other factors, the risk ratio (OR) of lung cancer when using e-cigarettes in combination with smoking was as high as 38.7, while the risk for smoking alone was 9.6.
Additional supporting evidence: Another study conducted in 2024 also reached a similar conclusion, finding that people who use both e-cigarettes and cigarettes have a lung cancer risk that is more than three times higher than that of smokers alone. Moreover, some research indicates that the risk for dual users could even be as high as four times greater.
Research on Biological Mechanisms
Scientific research is revealing how e-cigarettes may cause cancer:
Direct damage to DNA: The study found that the DNA of e-cigarette users showed similar cancer-related genetic changes to those of smokers.
Promoting tumor progression: Preclinical studies have shown that exposure to e-cigarettes can enhance the invasive behavior of human lung epithelial cells, especially in high-risk individuals who already have P53 and KRAS gene mutations (common mutations in lung cancer).
Animal experiment evidence: Animal experiments have also shown that mice exposed to e-cigarette smoke have a significantly increased risk of developing lung tumors.
Weakening the benefits of quitting smoking: A study by the International Agency for Research on Cancer (IARC) of the World Health Organization suggests that continuing to use e-cigarettes after quitting smoking may reduce the benefits of quitting in terms of lowering the risk of lung cancer and mortality.
⚠️ Warning from International Authorities
The World Health Organization (WHO) and other authoritative institutions have clearly stated:
E-cigarettes can produce toxic substances, some of which are known to cause cancer and increase the risk of developing heart and lung diseases.
Although nicotine itself is not a carcinogen, it may act as a "tumor inducer".
Summary
Overall, although electronic cigarettes have been on the market for a relatively short period of time, a "complete picture" of their long-term carcinogenic risks still requires more time. However, the concern that "electronic cigarettes cause lung cancer" is being increasingly supported by scientific evidence. Especially for young people who have never smoked and for those who both smoke and use electronic cigarettes, the risks are particularly prominent.